Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection.

@article{Kramer2010CrosstalkBH,
  title={Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection.},
  author={Matthijs Kramer and Barbara M. Schulte and Dagmar Eleveld-Tranc{\'i}kov{\'a} and Maaike A van Hout-Kuijer and Liza W J Toonen and Jurjen Tel and I Jolanda M de Vries and Frank J M van Kuppeveld and Bastiaan J.H. Jansen and Gosse J Adema},
  journal={Journal of innate immunity},
  year={2010},
  volume={2 4},
  pages={
          360-70
        }
}
Dendritic cells (DCs) are professional antigen-presenting cells that provide a link between innate and adaptive immunity. Multiple DC subsets exist and their activation by microorganisms occurs through binding of conserved pathogen-derived structures to so-called pattern recognition receptors (PRRs). In this study we analyzed the expression of PRRs responding to viral RNA in human monocyte-derived DCs (moDCs) under steady-state or pro-inflammatory conditions. We found that mRNA and protein… CONTINUE READING

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