Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner.

@article{Perret2012CrosstalkBS,
  title={Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner.},
  author={Magali Perret and C{\'e}dric Badiou and G{\'e}rard Lina and Sophie Burbaud and Yvonne Benito and Mich{\'e}le Bes and Vincent Cottin and Florence Couzon and Carole Juruj and Olivier Dauwalder and Nad{\`e}ge Goutagny and Binh An Diep and François Vandenesch and Thomas Henry},
  journal={Cellular microbiology},
  year={2012},
  volume={14 7},
  pages={1019-36}
}
Staphylococcus aureus is a major pathogen responsible for both nosocomial and community-acquired infections. Central to its virulence is its ability to secrete haemolysins, pore-forming toxins and cytolytic peptides. The large number of membrane-damaging toxins and peptides produced during S. aureus infections has hindered a precise understanding of their specific roles in diseases. Here, we used comprehensive libraries of recombinant toxins and synthetic cytolytic peptides, of S. aureus… CONTINUE READING

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