Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension.

@article{Teng2012CrossTB,
  title={Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension.},
  author={Ru-Jeng Teng and Jianhai Du and Scott Welak and Tongju Guan and Annie Eis and Yang Shi and Girija Ganesh Konduri},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2012},
  volume={302 7},
  pages={L651-63}
}
Autophagy is a process for cells to degrade proteins or entire organelles to maintain a balance in the synthesis, degradation, and subsequent recycling of cellular products. Increased reactive oxygen species formation is known to induce autophagy. We previously reported that increased NADPH oxidase (NOX) activity in pulmonary artery endothelial cells (PAEC) from fetal lambs with persistent pulmonary hypertension (PPHN) contributes to impaired angiogenesis in PPHN-PAEC compared with normal PAEC… CONTINUE READING

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