Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus

@inproceedings{Giunco2015CrossTB,
  title={Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus},
  author={Silvia Giunco and Alessia Celeghin and K Gianesin and Riccardo Dolcetti and Stefano Indraccolo and Anita De Rossi},
  booktitle={Cell Death and Disease},
  year={2015}
}
Epstein–Barr virus (EBV)-associated malignancies, as well as lymphoblastoid cell lines (LCLs), obtained in vitro by EBV infection of B cells, express latent viral proteins and maintain their ability to grow indefinitely through inappropriate activation of telomere-specific reverse transcriptase (TERT), the catalytic component of telomerase. Our previous studies demonstrated that high levels of TERT expression in LCLs prevent the activation of EBV lytic cycle, which is instead triggered by TERT… CONTINUE READING