Cross-talk between AMPK and mTOR in regulating energy balance.

  title={Cross-talk between AMPK and mTOR in regulating energy balance.},
  author={Jia Xu and Jian Ji and Xiang-hua Yan},
  journal={Critical reviews in food science and nutrition},
  volume={52 5},
Energy balance is maintained by a complex homeostatic system involving some signaling pathways and "nutrient sensors" in multiple tissues and organs. Any defect associated with the pathways can lead to metabolic disorders including obesity, type 2 diabetes, and the metabolic syndrome. The 5'-adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) appear to play a significant role in the intermediary metabolism of these diseases. AMPK is involved in the… CONTINUE READING


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Hypothalamic mTOR signaling regulates food intake.

Science • 2006
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