Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors.

@article{Beury2014CrosstalkAM,
  title={Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors.},
  author={Daniel W Beury and Katherine H. Parker and Maeva Nyandjo and Pratima Sinha and Kayla A Carter and Suzanne Ostrand-Rosenberg},
  journal={Journal of leukocyte biology},
  year={2014},
  volume={96 6},
  pages={1109-18}
}
MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells and MDSC or macrophages are less well studied. To examine potential interactions between these cells, we studied the impact of MDSC, macrophages, and four murine tumor cell lines on each other, both in vitro and in vivo. We focused on IL-6, IL… CONTINUE READING
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