Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.

@article{Wang2008CrosssubtypeAA,
  title={Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.},
  author={Shixia Wang and Jeffrey S. Kennedy and Kim Y West and David C. Montefiori and Scott E Coley and John Lawrence and Siyuan J. Shen and Sharone Green and Alan L Rothman and Francis A. Ennis and James Arthos and Ranajit Pal and Phillip D. Markham and Shan Da Nan Lu},
  journal={Vaccine},
  year={2008},
  volume={26 31},
  pages={
          3947-57
        }
}
An optimally effective AIDS vaccine would likely require the induction of both neutralizing antibody and cell-mediated immune responses, which has proven difficult to obtain in previous clinical trials. Here we report on the induction of human immunodeficiency virus type-1 (HIV-1)-specific immune responses in healthy adult volunteers that received the multi-gene, polyvalent, DNA prime-protein boost HIV-1 vaccine formulation, DP6-001, in a Phase I clinical trial. Robust cross-subtype HIV-1… CONTINUE READING

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