Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.

@article{Liang2006CrossspeciesVE,
  title={Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.},
  author={W Liang and Xiumin Wu and Franklin V. Peale and Chingwei Vivian Lee and Y. Gloria Meng and Johnny Gutierrez and Ling Fu and Ajay K. Malik and H L Gerber and Napoleone M. A. Ferrara and Germaine Fuh},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 2},
  pages={951-61}
}
To fully assess the role of VEGF-A in tumor angiogenesis, antibodies that can block all sources of vascular endothelial growth factor (VEGF) are desired. Selectively targeting tumor-derived VEGF overlooks the contribution of host stromal VEGF. Other strategies, such as targeting VEGF receptors directly or using receptor decoys, result in inhibiting not only VEGF-A but also VEGF homologues (e.g. placental growth factor, VEGF-B, and VEGF-C), which may play a role in angiogenesis. Here we report… CONTINUE READING
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