Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies.

@article{Wyrobek2005CrossspeciesSA,
  title={Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies.},
  author={Andrew J. Wyrobek and Thomas Ernst Schmid and Francesco Marchetti},
  journal={Environmental and molecular mutagenesis},
  year={2005},
  volume={45 2-3},
  pages={271-83}
}
The father, like the mother, can transmit genetic defects to his offspring that are detrimental for normal development and a healthy life. Epidemiological studies have identified associations between several paternal exposures and abnormal reproductive outcomes, but these types of studies are inherently complex and expensive, and the risk factors for the paternal contribution to abnormal reproductive outcomes remain poorly understood. Several sensitive methods have been developed for detecting… CONTINUE READING
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