Cross-species genomics matches driver mutations and cell compartments to model ependymoma

  title={Cross-species genomics matches driver mutations and cell compartments to model ependymoma},
  author={Robert A. Johnson and Karen D. Wright and Helen Poppleton and Kumarasamypet M. Mohankumar and David B. Finkelstein and Stanley B Pounds and Vikki Rand and Sarah E. S. Leary and E Lucille White and Christopher J. Eden and Twala L. Hogg and Paul A. Northcott and Stephen C Mack and Geoffrey Neale and Yong-Dong Wang and Beth Coyle and Jennifer M. Atkinson and Mariko D Dewire and Tanya A Kranenburg and Yancey Gillespie and Jeffrey B. Allen and Thomas E. Merchant and Fredrick A. Boop and Robert. A. Sanford and Amar Gajjar and D W Ellison and Michael D. Taylor and Richard G. Grundy and Richard J. Gilbertson},
Understanding the biology that underlies histologically similar but molecularly distinct subgroups of cancer has proven difficult because their defining genetic alterations are often numerous, and the cellular origins of most cancers remain unknown. We sought to decipher this heterogeneity by integrating matched genetic alterations and candidate cells of origin to generate accurate disease models. First, we identified subgroups of human ependymoma, a form of neural tumour that arises throughout… CONTINUE READING
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