Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences.

@article{Dalvie2010CrossspeciesCO,
  title={Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences.},
  author={Deepak K. Dalvie and Chenghong Zhang and Weichao Chen and Teresa A. Smolarek and R Scott Obach and Cho-Ming Loi},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 4},
  pages={641-54}
}
Excretion and metabolism of zoniporide were investigated in humans after intravenous infusion of [(14)C]zoniporide at an 80-mg dose. Bile was the primary route of excretion because 57% of dose was recovered in the feces after intravenous infusion. Zoniporide was primarily cleared via metabolism in humans. 2-Oxozoniporide (M1) was the major excretory and circulating metabolite in humans and was catalyzed by aldehyde oxidase (K(m) of 3.4 microM and V(max) of 74 pmol/min/mg protein). Metabolites… CONTINUE READING
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