Cross-species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation.

@article{Vuillaumier1997CrossspeciesCO,
  title={Cross-species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation.},
  author={Sandrine Vuillaumier and I Dixm{\'e}ras and H Messa{\"i} and Claudine L Lapoum{\'e}roulie and Dominique Lallemand and Jean Gekas and Fand F. Chehab and C. Perret and Jacques E Elion and Erick Denamur},
  journal={The Biochemical journal},
  year={1997},
  volume={327 ( Pt 3)},
  pages={651-62}
}
The cystic fibrosis transmembrane conductance regulator (CFTR) gene is highly conserved within vertebrate species. Its pattern of expression in vivo seems to be tightly regulated both developmentally and in a tissue-specific manner, but shows differences with species. To identify transcriptional regulatory elements in the CFTR promoter region, we have used a combined approach based both on the analysis of the chromatin structure in vivo in rat tissues and on evolutionary clues (i.e… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Gene and cell therapy for cystic fibrosis: from bench to bedside.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…