Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells

@article{Baki2015CrosssignalingIM,
  title={Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells},
  author={Lia Baki and Miguel Fribourg and Jason Younkin and Jos{\'e} Miguel Eltit and Jose Luis Moreno and Gyu Tae Park and Zhanna Vysotskaya and Adishesh K Narahari and Stuart C. Sealfon and Javier Gonz{\'a}lez-Maeso and Diomedes E. Logothetis},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2015},
  volume={468},
  pages={775-793}
}
We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011–1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signaling of the partner receptor. Importantly, through this cross-signaling, the mGlu2R/2AR heteromer integrates the actions of psychedelic and… CONTINUE READING
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