Cross-sensitization between caffeine- and l-dopa-induced behaviors in hemiparkinsonian mice

@article{Yu2006CrosssensitizationBC,
  title={Cross-sensitization between caffeine- and l-dopa-induced behaviors in hemiparkinsonian mice},
  author={L. Yu and M. Schwarzschild and J. Chen},
  journal={Neuroscience Letters},
  year={2006},
  volume={393},
  pages={31-35}
}
  • L. Yu, M. Schwarzschild, J. Chen
  • Published 2006
  • Chemistry, Medicine
  • Neuroscience Letters
  • Adenosine A(2A) receptor (A(2A)R) antagonists, including the non-specific adenosine antagonist caffeine, have been proposed as a novel, non-dopaminergic treatment strategy for Parkinson's disease (PD). However, the long-term interaction between caffeine and L-dopa treatment in PD models has not been characterized. We examined the interaction between caffeine and L-dopa following a repeated treatment paradigm in hemiparkinsonian mice. In contrast to the progressively sensitized rotational… CONTINUE READING
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