Cross-sectional study of bone metabolism with nutrition in adult classical phenylketonuric patients diagnosed by neonatal screening

@article{Nagasaka2011CrosssectionalSO,
  title={Cross-sectional study of bone metabolism with nutrition in adult classical phenylketonuric patients diagnosed by neonatal screening},
  author={Hironori Nagasaka and Hirokazu Tsukahara and Tomozumi Takatani and Yoshitami Sanayama and Masaki Takayanagi and Toshihiro Ohura and Osamu Sakamoto and Tetsuya Ito and Mika Wada and Makoto Yoshino and Akira Ohtake and Tohru Yorifuji and Satoshi Hirayama and Takashi Miida and Hiroki Fujimoto and Hiroshi Mochizuki and Toshikazu Hattori and Yoshiyuki Okano},
  journal={Journal of Bone and Mineral Metabolism},
  year={2011},
  volume={29},
  pages={737-743}
}
The mechanism underlying the development of osteopenia or osteoporosis in longstanding phenylketonuria (PKU) remains to be clarified. We investigated the details of bone metabolism in 21 female and 13 male classical PKU patients aged 20–35 years. Vitamin D (VD), parathyroid hormone (PTH), bone turnover markers, and daily nutrient intake were examined. The patients had lower daily energy and protein intake than did the age-matched controls (22 women, 14 men), but their respective fat, VD, and… CONTINUE READING