Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of aging.

@article{Franz2011CrosssectionalA3,
  title={Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era twin study of aging.},
  author={Carol E. Franz and Robert C. O'Brien and Richard L. Hauger and Sally P. Mendoza and Matthew S. Panizzon and Elizabeth Prom-Wormley and Lindon J. Eaves and Kristen C. Jacobson and Michael J Lyons and Sonia J. Lupien and Dirk H. Hellhammer and Hong Xian and William S. Kremen},
  journal={Psychoneuroendocrinology},
  year={2011},
  volume={36 7},
  pages={1040-52}
}
High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol… CONTINUE READING

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