Cross resistance relevance of the chemical structure of different anthracyclines in multidrug resistant cells.

@article{Tapiero1994CrossRR,
  title={Cross resistance relevance of the chemical structure of different anthracyclines in multidrug resistant cells.},
  author={Haim Tapiero and G Nguyen-Ba and Theodore J. Lampidis},
  journal={Pathologie-biologie},
  year={1994},
  volume={42 4},
  pages={328-37}
}
Positively charged doxorubicin (DOX) and non-positively charged anthracyclines, aclarubicin (ACR) and morpholino-carminomycin (KRN 8602), have been investigated with respect to pharmacological parameters, cytotoxicity, DNA damage and repair in DOX-sensitive and -resistant murine and human cells. Friend leukemia cells (FLC) resistant to high concentrations of doxorubicin (DOX-RFLC3) or daunorubicin (DNR-RFLC3) (1771 and 1543 fold resistance respectively) express less than 10 fold resistance to… CONTINUE READING