Cross-resistance patterns in ACNU-resistant glioma sublines in culture.

@article{Saito1991CrossresistancePI,
  title={Cross-resistance patterns in ACNU-resistant glioma sublines in culture.},
  author={Y. Saito and Y. Nakada and T. Hotta and T. Mikami and K. Kurisu and K. Yamada and K. Kiya and K. Kawamoto and T. Uozumi},
  journal={Journal of neurosurgery},
  year={1991},
  volume={75 2},
  pages={
          277-83
        }
}
  • Y. Saito, Y. Nakada, +6 authors T. Uozumi
  • Published 1991
  • Biology, Medicine
  • Journal of neurosurgery
  • Three ACNU-resistant clones (R1, R3, and R12) were isolated from 9L rat glioma cells under selection pressure of ACNU in vitro. The authors have investigated the mechanisms of resistance and characteristics of these clones at the cellular level by studying cross-resistance patterns to chemical and physical agents. Although these resistant sublines showed complete cross-resistance to methyl-chloroethylnitrosourea (MCNU), no cross-resistance was observed for other alkylating agents, while each of… CONTINUE READING

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