Cross-resistance of drug-resistant murine P388 leukemias to toxol in vivo

  title={Cross-resistance of drug-resistant murine P388 leukemias to toxol in vivo},
  author={William R. Waud and Karen S. Gilbert and Steadman D. Harrison and Daniel P. Griswold},
  journal={Cancer Chemotherapy and Pharmacology},
The antimicrotubule agent taxol (NSC 125973) has shown clinical antitumor activity against several classically refractory tumors. We developed a drug-resistance profile for taxol using ten drug-resistant P388 leukemias to identify potentially useful guides for patient selection for further clinical trials of taxol and possible non-cross-resistant drug combinations with taxol. Multidrug-resistant P388 leukemias exhibited either clear (leukemia resistant to amsacrine) or marginal cross-resistance… CONTINUE READING
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