Cross-resistance of drug-resistant murine P388 leukemias to toxol in vivo

@article{Waud1992CrossresistanceOD,
  title={Cross-resistance of drug-resistant murine P388 leukemias to toxol in vivo},
  author={William R. Waud and Karen S. Gilbert and Steadman D. Harrison and Daniel P. Griswold},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1992},
  volume={31},
  pages={255-257}
}
The antimicrotubule agent taxol (NSC 125973) has shown clinical antitumor activity against several classically refractory tumors. We developed a drug-resistance profile for taxol using ten drug-resistant P388 leukemias to identify potentially useful guides for patient selection for further clinical trials of taxol and possible non-cross-resistant drug combinations with taxol. Multidrug-resistant P388 leukemias exhibited either clear (leukemia resistant to amsacrine) or marginal cross-resistance… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 11 references

Therapeutic resistance in leukemia. In: Teicher BA (ed) Mechanisms of drug resistance in oncology

  • WR Wand, Griswold DP
  • 1992
2 Excerpts

Application of tumor models toward the design of treatment schedules for cancer chemotherapy

  • HH Lloyd
  • 1977
1 Excerpt

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