Cross-resistance in Pseudomonas aeruginosa resistant to phenylethanol.

@article{Richards1972CrossresistanceIP,
  title={Cross-resistance in Pseudomonas aeruginosa resistant to phenylethanol.},
  author={R. Michael E. Richards and R. J. Mcbride},
  journal={Journal of pharmaceutical sciences},
  year={1972},
  volume={61 7},
  pages={
          1075-7
        }
}
The effects of benzalkonium, chlorhexidine, and phenyl-mercuric nitrate on exponential phase cultures of phenylethanol-sensitive Pseudomonas aeruginosa NCTC 6750 growing in nutrient broth and on phenylethanol-resistant cells growing in nutrient broth plus 0.2% phenylethanol v/v were determined. The resistant cultures grown in the presence of phenylethanol were more sensitive to benzalkonium, chlorhexidine, and phenylmercuric nitrate than phenylethanol-sensitive cells grown in nutrient broth… Expand
8 Citations
Pseudomonas cepacia resistance to antibacterials.
TLDR
P. cepacia had a markedly different resistance pattern to single and combined antibacterials from that characteristic of Pseudomonas aeruginosa, which has relevance to hospital disinfection and preservation of pharmaceutical solutions. Expand
Antipseudomonal effect of polymyxin and phenylethanol.
TLDR
It is suggested that there is no cross-resistance between polymyxin and either benzalkonium chloride or chlorhexidine acetate. Expand
Enhancement of benzalkonium chloride and chlorhexidine acetate activity against Pseudomonas aeruginosa by aromatic alcohols.
The actions of benzalkonium chloride and chlorhexidine acetate in combination with benzyl alcohol, 2-phenylethanol, or 3-phenylpropanol were evaluated at subinhibitory concentrations by measuring theExpand
Effect of 3-phenylpropan-1-ol, 2-phenylethanol, and benzyl alcohol on Pseudomonas aeruginosa.
TLDR
3-phenylpropan-1-ol may be a suitable preservative for oral suspensions and mixtures and enhance the bactericidal action of benzalkonium chloride against P. aeruginosa in the same ranking order. Expand
MECHANISTIC INVESTIGATIONS OF THE OXIDATION OF SUBSTITUTED PHENETHYL ALCOHOLS BY MANGANESE(III) SULFATE CATALYZED BY RUTHENIUM(III) IN ACID SOLUTION
The kinetics of the Ru(III) catalysed oxidation of six derivatives of phenethyl alcohol (X-C6H4-CH2CH2OH where X═H, Cl, Br, CH3, OCH3 or NO2) by manganese(III) sulfate, in sulfuric acid solution atExpand
Exploiting thermoresponsive polymers to modulate lipophilicity: interactions with model membranes.
TLDR
Membrane perturbation assays and linear dichroism spectroscopy investigations suggest that POEGMAs above their transition temperatures can interact with, or insert into, membranes, which will help develop the application of responsive polymers in drug delivery. Expand
Benzalkonium chloride: A systematic review of its environmental entry through wastewater treatment, potential impact, and mitigation strategies
Benzalkonium chloride is a concern because of its widespread use combined with environmental impacts. It has been found throughout the built and natural environment in wastewater influent, effluent...
Pharmaceutical sciences--1972: literature review of pharmaceutics. I.

References

SHOWING 1-6 OF 6 REFERENCES
Survival of Pseudomonas aeruginosa in fluorescein solution. Preservative action of PMN and EDTA
Colony counts were made for a year on washed and unwashed cells of Ps. aeruginosa inoculated into fluorescein sodium solution, 2 percent in water (pH 8.6), into nutrient broth, into tris buffer (pHExpand
EFFECTIVENESS OF ANTIBACTERIAL AGENTS PRESENTLY EMPLOYED IN OPHTHALMIC PREPARATIONS AS PRESERVATIVES AGAINST PSEUDOMONAS AERUGINOSA.
Seven chemical substances or combinations of these substances presently employed as preservatives in ophthalmic solutions were studied to note their effectiveness as antibacterial agents against 13Expand
Preservation of fluorescein solutions against contamination with Pseudomonas aeruginosa
A combination of phenylmercuric nitrate and phenylethyl alcohol was more effective in preserving fluorescein solutions against contamination with P. aeruginosa than phenylmercuric nitrate alone. P.Expand
Mechanism of action of phenethyl alcohol: breakdown of the cellular permeability barrier.
TLDR
It is proposed that the primary effect of PEA is a limited breakdown of the cell membrane, and the inhibition of deoxyribonucleic acid synthesis and other cellular functions would be secondary consequences of the alteration in the membrane structure. Expand
Preservation of sodium bicarbonate eye lotion BPC against contamination with Pseudomonas aeruginosa.
TLDR
It has been suggested that a sterilizing time of I hour or less is what should be expected of an antibacterial substance considered suitable for the preservation of ophthalmic solutions, and 2-phenylethanol (PEA) is a more effective preservative system for fluorescein sodium eye drops than the official BPC formulation, which is preserved with PMN alone. Expand
The preservation of ophthalmic solutions with antibacterial combinations
TLDR
Phenylethanol‐antibacterial combinations were consistently effective in killing the inoculum within 15 min except for one formulation with chlorhexidine and physostigmine salicylate and formulations with PMN for which sterilization times ranged from 30 to 90 min. Expand