Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.

@article{Plaza2008CrossregulatoryPI,
  title={Cross-regulatory protein-protein interactions between Hox and Pax transcription factors.},
  author={S Fern{\'a}ndez Plaza and Fr{\'e}d{\'e}ric Prince and Yoshitsugu Adachi and Claudio Punzo and David L. Cribbs and W. J. Gehring},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 36},
  pages={13439-44}
}
Homeotic Hox selector genes encode highly conserved transcriptional regulators involved in the differentiation of multicellular organisms. Ectopic expression of the Antennapedia (ANTP) homeodomain protein in Drosophila imaginal discs induces distinct phenotypes, including an antenna-to-leg transformation and eye reduction. We have proposed that the eye loss phenotype is a consequence of a negative posttranslational control mechanism because of direct protein-protein interactions between ANTP… CONTINUE READING

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