Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens.

@article{Arrenberg2009CrossregulationBD,
  title={Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens.},
  author={Philomena Arrenberg and Ramesh Chandra Halder and Vipin Kumar},
  journal={Journal of cellular physiology},
  year={2009},
  volume={218 2},
  pages={246-50}
}
Natural killer T (NKT) cells generally recognize lipid-antigens presented in the context of the MHC class I-like molecule CD1d. CD1d-restricted NKT cells consist of two broad subsets: Type I, which express an invariant T cell receptor (TCR) and type II, which utilize diverse TCR gene segments. A major type II NKT subset has been shown to recognize a self-glycolipid, sulfatide. Both subsets play important roles in autoimmune diseases, tumor surveillance, and infectious diseases. While type I NKT… CONTINUE READING

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