Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop.

@article{Pines2005CrossregulationBE,
  title={Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop.},
  author={Alex Pines and Nicoletta Bivi and Milena Romanello and Giuseppe Damante and Mark R Kelley and E. D. Adamson and Paola D'andrea and Franco Quadrifoglio and L. C. Moro and Gianluca Tell},
  journal={Free radical research},
  year={2005},
  volume={39 3},
  pages={269-81}
}
The Early Growth Response protein (Egr-1) is a C(2)H(2)-zinc finger-containing transcriptional regulator involved in the control of cell proliferation and apoptosis. Its DNA-binding activity is redox regulated in vitro through the oxidation-reduction of Cys residues within its DNA-binding domain. APE/Ref-1 is a DNA-repair enzyme with redox modulating activities on several transcription factors. In this study, by evaluating the effects of different stimuli, we found a similar timing of… CONTINUE READING

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