Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease.

@article{Elkington2005CrossrecognitionOH,
  title={Cross-recognition of human alloantigen by cytomegalovirus glycoprotein-specific CD4+ cytotoxic T lymphocytes: implications for graft-versus-host disease.},
  author={Rebecca J. Elkington and Rajiv Khanna},
  journal={Blood},
  year={2005},
  volume={105 3},
  pages={1362-4}
}
Presence of the HLA-DR7 allele in patients who receive transplants has been proposed as a risk factor for human cytomegalovirus (HCMV)-associated complications; however, the precise mechanism of this increased risk remains unresolved. Here we show that HLA-DR7-restricted HCMV-specific CD4(+) cytotoxic T lymphocytes (CTLs) can display an unusual dual specificity toward a glycoprotein-B (gB) epitope and the alloantigen HLA-DR4. However, no HLA-DR4-specific alloreactivity was observed when the gB… CONTINUE READING

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