Cross-reactivity to Borrelia burgdorferi proteins in serum samples from residents of a tropical country nonendemic for Lyme disease.

@article{Burkot1997CrossreactivityTB,
  title={Cross-reactivity to Borrelia burgdorferi proteins in serum samples from residents of a tropical country nonendemic for Lyme disease.},
  author={Thomas R. Burkot and Martin E. Schriefer and Stine Anna Larsen},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={175 2},
  pages={466-9}
}
Reports of Lyme disease from areas where the disease is not endemic have increased. Eighty-six human serum samples from Papua New Guinea (nonendemic for Lyme disease) were examined for the presence of IgG antibodies that recognize Borrelia burgdorferi antigens, using the currently recommended two-tiered system of analysis (sensitive ELISA with Western blot). The percentage of positive tests dropped from 50% to 10% when individual negative controls were included in the two-tiered analysis… CONTINUE READING