Cross-reactivity of a human IgG₁ anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide.

@article{Trier2012CrossreactivityOA,
  title={Cross-reactivity of a human IgG₁ anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide.},
  author={Nicole Hartwig Trier and Maria Louise Leth and Paul Robert Hansen and Gunnar Houen},
  journal={Protein science : a publication of the Protein Society},
  year={2012},
  volume={21 12},
  pages={
          1929-41
        }
}
Rheumatoid arthritis (RA) is the most common autoimmune rheumatic disease. It is characterized by persistent joint inflammation, resulting in loss of joint function, morbidity and premature mortality. The presence of antibodies against citrullinated proteins is a characteristic feature of RA and up to 70% of RA patients are anticitrullinated protein antibody (ACPA) positive. ACPA responses have been widely studied and are suggested to be heterogeneous, favoring antibody cross-reactivity to… CONTINUE READING
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