Cross-reactive phage-displayed mimotopes lead to the discovery of mimicry between HSV-1 and a brain-specific protein.

@article{Cortese2001CrossreactivePM,
  title={Cross-reactive phage-displayed mimotopes lead to the discovery of mimicry between HSV-1 and a brain-specific protein.},
  author={Irene Cortese and Silvana Capone and Sabina Luchetti and R. Cortese and Alfredo Nicosia},
  journal={Journal of neuroimmunology},
  year={2001},
  volume={113 1},
  pages={119-28}
}
We previously reported the selection of several families of phage-displayed peptide mimics (mimotopes) recognized by oligoclonal immunoglobulins present in the CSF of multiple sclerosis (MS) patients. To search for the natural antigens recognized by these antibodies, anti-sera were raised against one of the mimotopes and used as a probe in ELISA, Western blotting and immunoprecipitation experiments. Anti-mimotope IgG were found to cross-react with an epitope shared by a brain-specific factor… CONTINUE READING