Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals.

@article{Sharma2006CrossreactiveCR,
  title={Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals.},
  author={Madeva C Sharma and Wendy Zhou and Joy Martinez and Ludmila Krymskaya and Tumul Srivastava and Wahajul Haq and Don J Diamond and Simon F Lacey},
  journal={Virology},
  year={2006},
  volume={350 1},
  pages={128-36}
}
Two HLA-A*02-restricted epitopes have been identified within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Immunization of transgenic mice with recombinant modified vaccinia Ankara expressing BKV VP1 (rMVA-BKV VP1) elicited functional CTL populations recognizing the sequences LLMWEAVTV (amino acids residues 108-116, BKV VP1p108) and AITEVECFL (residues 44-52, BKV VP1p44) and cross-reactive to… CONTINUE READING

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