Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial.

@article{Clemens1988CrossprotectionBB,
  title={Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: results of a large-scale field trial.},
  author={John David Clemens and David A Sack and Jennifer R. Harris and J. Chakraborty and P K Neogy and B F Stanton and Nighat Huda and Moslem Uddin Khan and Bradford Kay and M R Khan},
  journal={The Journal of infectious diseases},
  year={1988},
  volume={158 2},
  pages={
          372-7
        }
}
The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are antigenically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared… CONTINUE READING

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