Cross-priming of CD8(+) T cells in vivo by dendritic cells pulsed with autologous apoptotic leukemic cells in immunotherapy for elderly patients with acute myeloid leukemia.

@article{Kitawaki2011CrossprimingOC,
  title={Cross-priming of CD8(+) T cells in vivo by dendritic cells pulsed with autologous apoptotic leukemic cells in immunotherapy for elderly patients with acute myeloid leukemia.},
  author={Toshio Kitawaki and Norimitsu Kadowaki and Keiko Fukunaga and Yasunari Kasai and Taira Maekawa and Katsuyuki Ohmori and Tatsuya Itoh and Akira Shimizu and Kiyotaka Kuzushima and Tadakazu Kondo and Takayuki Ishikawa and Takashi Uchiyama},
  journal={Experimental hematology},
  year={2011},
  volume={39 4},
  pages={424-433.e2}
}
OBJECTIVE The prognosis for elderly patients with acute myeloid leukemia (AML) remains dismal. To explore the potential of immunotherapy for improving clinical outcomes for these patients, we performed a phase I clinical trial of dendritic cell (DC)-based immunotherapy for elderly patients with AML. MATERIALS AND METHODS Autologus monocytes were obtained after reducing tumor burden by chemotherapy. Immature DCs induced with granulocyte-macrophage colony-stimulating factor and interleukin-4… CONTINUE READING