Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression.

@article{Sotomayor2001CrosspresentationOT,
  title={Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression.},
  author={Eduardo M. Sotomayor and Ivan Borrello and Fr{\'e}d{\'e}rique Marie Rattis and Alex Gervacio Cuenca and Judith Abrams and Kevin Staveley-O'Carroll and Hyam I. Levitsky},
  journal={Blood},
  year={2001},
  volume={98 4},
  pages={1070-7}
}
Tumor antigen-specific T-cell tolerance may limit the efficacy of therapeutic cancer vaccines. Direct presentation of antigens by tumor cells incapable of providing adequate costimulation to tumor-specific T cells has been suggested as the basis for this unresponsiveness. Using parent-into-F1 bone marrow (BM) chimeras, this study unambiguously demonstrates that the induction of this tolerant state requires T-cell recognition of tumor antigen presented by BM-derived antigen-presenting cells… CONTINUE READING
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