Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins.

@article{Basta2005CrosspresentationOT,
  title={Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins.},
  author={Sameh Basta and Ricarda Stoessel and Michael Basler and Maries van den Broek and Marcus Groettrup},
  journal={Journal of immunology},
  year={2005},
  volume={175 2},
  pages={
          796-805
        }
}
Many viral proteins that contain MHC class I-restricted peptides are long-lived, and it is elusive how they can give rise to class I epitopes. Recently, we showed that direct presentation of an epitope of the long-lived lymphocytic choriomeningitis virus nucleoprotein (LCMV-NP) required neosynthesis in accordance with the defective ribosomal products hypothesis. In this study, we report that LCMV-NP can be cross-primed in mice using either LCMV-NP-transfected human HEK293 or BALB/c-derived B8… CONTINUE READING

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