Cross-presentation: underlying mechanisms and role in immune surveillance.

  title={Cross-presentation: underlying mechanisms and role in immune surveillance.},
  author={Kenneth L. Rock and Lianjun Shen},
  journal={Immunological reviews},
It was originally thought that a cell's major histocompatibility complex (MHC) class I molecules presented peptides derived exclusively from proteins synthesized by the cell itself. However, in some circumstances, antigens from the extracellular environment can be presented on MHC class I molecules and stimulate CD8(+) T-cell immunity, a process termed cross-presentation. Cross-presentation was originally discovered as an obscure phenomenon in transplantation immunity. However, it is now clear… CONTINUE READING


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