Cross-modal and cross-temporal association in neurons of frontal cortex

  title={Cross-modal and cross-temporal association in neurons of frontal cortex},
  author={Joaqu{\'i}n M. Fuster and Mark Bodner and James K. Kroger},
The prefrontal cortex is essential for the temporal integration of sensory information in behavioural and linguistic sequences. Such information is commonly encoded in more than one sense modality, notably sight and sound. Connections from sensory cortices to the prefrontal cortex support its integrative function. Here we present the first evidence that prefrontal cortex cells associate visual and auditory stimuli across time. We gave monkeys the task of remembering a tone of a certain pitch… 

Auditory connections and functions of prefrontal cortex

Past research in humans indicates that specific task conditions, stimuli or previous experience may bias the recruitment of specific prefrontal regions, suggesting a more flexible role for the frontal lobe during auditory cognition.

Integration of Auditory and Visual Communication Information in the Primate Ventrolateral Prefrontal Cortex

This study demonstrates, for the first time, that single prefrontal neurons in the macaque ventrolateral prefrontal cortex integrate communication information from the auditory and visual domains, suggesting that these neurons are an important node in the cortical network responsible for communication.

Comparison of differential neuronal responsiveness for different regions of the prefrontal cortex in a conditional visual discrimination task

Compared to temporal neurons, prefrontal responses more frequently coded information relating to the planned behavioural response rather than perceptual aspects of the task, indicating potential information flow was likely to be primarily from temporal to prefrontal cortex rather than vice versa.

Processing of auditory and visual location information in the monkey prefrontal cortex

The results of the present study suggest that in addition to the modality specific parallel mechanism, working memory of auditory and visual space also involves modality independent processing at cellular level in the PFCd.

Choice-dependent cross-modal interaction in the medial prefrontal cortex of rats

Cross-modal interaction (CMI) could significantly influence the perceptional or decision-making process in many circumstances. However, it remains poorly understood what integrative strategies are

Differential roles of delay-period neural activity in the monkey dorsolateral prefrontal cortex in visual–haptic crossmodal working memory

Results indicate that neural networks in the DLPFC function sequentially in the cross modal task from visual stimulus encoding and crossmodal information transferring between visual and tactile stimuli to the behavioral action.

Neural Substrate of Initiation of Cross-Modal Working Memory Retrieval

A cued matching task revealed that the frontoparietal-thalamus network participated in the initiation of cross-modal working memory retrieval, and the l-SPL and thalamus showed differential activations between maintenance and working memory retrieved, which might be associated with the enhanced demand for cognitive resources.

Persistent neuronal activity in human prefrontal cortex links perception and action

Intracranial recordings from epileptic patients during a number of different behavioural tasks reveal, in impressive spatiotemporal detail, that the human brain links perception and action through persistent neural activity in the prefrontal cortex and functionally linked brain regions.

Neural correlates of auditory recognition memory in primate lateral prefrontal cortex

Possible Functions of Prefrontal Cortical Neurons in Duration Discrimination

  • K. Oshio
  • Biology, Psychology
    Front. Integr. Neurosci.
  • 2011
Results suggest that PFC neurons not only encode duration category, but also implement strategic processes such as the representation of trial type (LS or SL) and the retention of cue information during cue and/or delay periods.



Neuronal activity of somatosensory cortex in a cross-modal (visuo-haptic) memory task

These findings suggest that units in somatosensory cortex react to visual stimuli behaviorally associated with tactile information and suggest that some of these neurons are involved in short-term active memory and may be part of cross-modal memory networks.

Neuronal correlates of parametric working memory in the prefrontal cortex

It is predicted that other behavioural tasks that require ordinal comparisons between scalar analogue stimuli would give rise to monotonic responses similar to those reported here.

Neuronal correlate of visual associative long-term memory in the primate temporal cortex

The results indicate that the selectivity acquired by cells in the anterior ventral temporal cortex of monkeys represents a neuronal correlate of the associative long-term memory of pictures.

Sensory modality specificity of neural activity related to memory in visual cortex.

The results suggest that neurons in inferotemporal cortex contribute to abstract memory representations that can be activated by input from other sensory modalities, but these representations are specific to visual behaviors.

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex.

An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.

Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks

Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task

  • J. FusterJ. Jervey
  • Psychology, Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1982
The data do not support a clear-cut topographic separation of visual functions within the inferotmeporal cortex, however, neurons that appear to participate in visual memory, either exclusively or in addition to other functions, are concentrated in the cortex of the lower banks of the superior temporal sulcus.

Functional interactions between inferotemporal and prefrontal cortex in a cognitive task

Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.

  • J. Fuster
  • Psychology, Biology
    Journal of neurophysiology
  • 1973
A question of particular interest is whether prefrontal neuron discharge during the clelay period differs from discharge in intertrial periods, even though the physical characteristics of the animal’s environment are identical in the two conditions.

Responses of inferior temporal cortex and hippocampal neurons during delayed matching to sample in monkeys (Macaca fascicularis).

The authors noted that the level of delay activity was generally larger in the hippocampus than in IT cortex, and unlike IT cortex delay activity, hippocampal delay activity tended to increase in magnitude as the delay progressed.