Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program.

@article{Chieppa2003CrosslinkingOT,
  title={Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program.},
  author={Marcello Chieppa and Giancarlo Bianchi and Andrea Doni and Annalisa Del Prete and Marina Sironi and Gordana Laskarin and Paolo Monti and Lorenzo Piemonti and Andrea Biondi and Alberto Mantovani and Martino Introna and Paola Allavena},
  journal={Journal of immunology},
  year={2003},
  volume={171 9},
  pages={4552-60}
}
Immature monocyte-derived dendritic cells (DC) strongly express the endocytic mannose receptor (MR). Addition of a specific anti-MR mAb (clone PAM-1) for 24 h to cultures of immature DC induced phenotypical and functional maturation of the cells, assessed as up-regulation of costimulatory molecules and CD83, and chemotactic response to CCL19. A different isotype-matched anti-MR mAb (clone 19.2) had no significant effect. Engagement of MR with mAb PAM-1 induced the production of the anti… CONTINUE READING

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