Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation.

@article{Kuijpers1993CrosslinkingOT,
  title={Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation.},
  author={Taco Willem Kuijpers and C. Ellen van der Schoot and Maarten Hoogerwerf and David A. Roos},
  journal={Journal of immunology},
  year={1993},
  volume={151 9},
  pages={4934-40}
}
The carcinoembryonic Ag (CEA)-like glycoproteins present on human granulocytes have been designated non-specific cross-reacting Ag (NCA). We have recently demonstrated that granulocyte-specific CD66 and CD67 mAb recognize the three originally described NCA. CD66 binds to NCA-160 and NCA-90, whereas CD67 only recognizes NCA-95. As we have shown previously, NCA-160 and NCA-90 present sialylated Lewis-X oligosaccharide Ag (SLex) in a functional way, i.e., these Ag function as (one of many possible… CONTINUE READING

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