Cross-linking of surface IgM activates NF-kappa B in B lymphocyte.

  title={Cross-linking of surface IgM activates NF-kappa B in B lymphocyte.},
  author={John W. Rooney and Paul M. Dubois and Carol Hopkins Sibley},
  journal={European journal of immunology},
  volume={21 12},
In B lymphocytes, cross-linking of surface IgM activates changes in both the cell cycle and differentiation. In normal B cells and B cell tumors, many stimuli induce the activation of NF-kappa B and its translocation from the cytoplasm to the nucleus. In this study we sought to determine if cross-linking of surface IgM led to the activation of NF-kappa B. Our results show that activation of B cells by cross-linking anti-IgM antibodies activated NF-kappa B in the murine B lymphoid cell lines 70Z… CONTINUE READING

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