Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism

When antibody to immunoglobulin (anti-Ig) reacts with Ig molecules on B-lymphocyte surfaces the Ig, tethered by the antibody, moves over the surface to form patches and finally a cap at one pole of the cell. Simultaneously, the Ig–antibody complexes are removed by pinocytosis at the patches and cap, until the surface is cleared of the target molecules1,2… (More)