Cross-linking of MHC class I molecules on human NK cells inhibits NK cell function, segregates MHC I from the NK cell synapse, and induces intracellular phosphotyrosines.

@article{Rubio2004CrosslinkingOM,
  title={Cross-linking of MHC class I molecules on human NK cells inhibits NK cell function, segregates MHC I from the NK cell synapse, and induces intracellular phosphotyrosines.},
  author={Gonzalo Rubio and Xavier F{\'e}rez and Mar{\'i}a S{\'a}nchez-Campillo and Jes{\'u}s G{\'a}lvez and Salvador Mart{\'i} and Roc{\'i}o Verd{\'u} and Trinidad Hern{\'a}ndez-Caselles and Pilar Garc{\'i}a-Pe{\~n}arrubia},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={76 1},
  pages={116-24}
}
Engagement of major histocompatibility complex (MHC) class I molecules on immune cells, where they are usually highly expressed, induces signal transduction events of unclear significance. We show here that antibody-mediated cross-linking of MHC-I molecules on human natural killer (NK) cells inhibits their cytotoxic activity against tumor target cells. Inhibition by anti-MHC class I monoclonal antibody exhibits molecular specificity and is an isotype and Fc-independent process. Physical… CONTINUE READING
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