Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes.

@article{Rothlein1994CrosslinkingOI,
  title={Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes.},
  author={Robert Rothlein and Takashi Kishimoto and Elizabeth A Mainolfi},
  journal={Journal of immunology},
  year={1994},
  volume={152 5},
  pages={2488-95}
}
Cell adhesion molecules were first described as accessory molecules simply to bridge one cell to another. More recently, it has been realized that these molecules also transmit signals from outside of the cell to inside. We show that cross-linking of the ICAM-1 on the cell membrane with anti-ICAM-1 mAb and F(ab')2 fragments of goat anti-MIgG in the presence of suboptimal levels of the bacterial peptide FMLP results in co-stimulation of an oxidative burst from CD14 expressing PBMCs. The… CONTINUE READING

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