Cross-linking of DNA through HMGA1 suggests a DNA scaffold

@inproceedings{Vogel2011CrosslinkingOD,
  title={Cross-linking of DNA through HMGA1 suggests a DNA scaffold},
  author={Benjamin Vogel and Anna L{\"o}schberger and Markus Sauer and Robert Hu Chang Hock},
  booktitle={Nucleic acids research},
  year={2011}
}
Binding of proteins to DNA is usually considered 1D with one protein bound to one DNA molecule. In principle, proteins with multiple DNA binding domains could also bind to and thereby cross-link different DNA molecules. We have investigated this possibility using high-mobility group A1 (HMGA1) proteins, which are architectural elements of chromatin and are involved in the regulation of multiple DNA-dependent processes. Using direct stochastic optical reconstruction microscopy (dSTORM), we could… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

HMG modifications and nuclear function.

  • Biochimica et biophysica acta
  • 2010
VIEW 1 EXCERPT

HMGA and cancer.

  • Biochimica et biophysica acta
  • 2010