Cross-linking of CD30 induces HIV expression in chronically infected T cells.


CD30, a member of the tumor necrosis factor (TNF) receptor family, is expressed constitutively on the surface of the human T cell line ACH-2, which is chronically infected with human immunodeficiency virus type-1 (HIV)-1. We demonstrate that cross-linking CD30 with an anti-CD30-specific monoclonal antibody, which mimics the described biological activities of the CD30 ligand (CD30L), results in HIV expression. CD30 cross-linking does not alter proliferation of ACH-2 cells and the induction of HIV expression is not mediated by endogenous TNF alpha/beta. Furthermore, cross-linking of CD30 leads to NF-kappa B activation and enhanced HIV transcription. Thus, CD30-CD30L interactions mediate the induction of HIV expression by a kappa B-dependent pathway that is independent of TNF. This mechanism may be important in the activation of HIV expression from latently infected CD4+ T cells, especially in lymphoid organs where cell to cell contact is conducive to receptor-ligand interactions.

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@article{Biswas1995CrosslinkingOC, title={Cross-linking of CD30 induces HIV expression in chronically infected T cells.}, author={Priscilla Biswas and Clyde A. Smith and Delia Goletti and Elaine C. Hardy and Robert W. Jackson and A. S. Fauci}, journal={Immunity}, year={1995}, volume={2 6}, pages={587-96} }