Cross-linked hemoglobin increases fractional reabsorption and GFR in hypoxic isolated perfused rat kidneys.

@article{Baines1995CrosslinkedHI,
  title={Cross-linked hemoglobin increases fractional reabsorption and GFR in hypoxic isolated perfused rat kidneys.},
  author={Anita Davelos Baines and B. Robert Christoff and David Andrew Wicks and Dc Wiffen and Diana Helen Pliura},
  journal={The American journal of physiology},
  year={1995},
  volume={269 5 Pt 2},
  pages={
          F628-36
        }
}
We compared the ability of human red blood cells (RBC) and a cell-free oxygen carrier to maintain isolated perfused kidney function under moderately hypoxic conditions. Recirculating perfusate was gassed initially with 93% air-7% CO2, and, after 30 min, the gas was changed to 12 O2-7 CO2-81% N2. Oxygen content of the perfusate was increased with RBC (30 g/l Hbg) or highly purified human hemoglobin Ao (HbAo) polymerized with O-raffinose (o-R-poly-Hb, 30 g/l Hbg). For comparison, kidneys were… CONTINUE READING
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