Cross-linked beta-cyclodextrin microcapsules. II. Retarding effect on drug release through semi-permeable membranes.

@article{Pariot2002CrosslinkedBM,
  title={Cross-linked beta-cyclodextrin microcapsules. II. Retarding effect on drug release through semi-permeable membranes.},
  author={N Pariot and Florence Edwards-L{\'e}vy and M C Andry and M C L{\'e}vy},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={232 1-2},
  pages={175-81}
}
Microcapsules were prepared by interfacial cross-linking of beta-cyclodextrins (beta-CD) with terephthaloylchloride (TC) as described previously. Complexation assays were conducted with propranolol HCl. After 1 h incubation of 50 mg lyophilized microcapsules in 10 ml propranolol solution, the amounts of fixed drug were 507.5+/-8.6 micromol and 811.2+/-16.0 micromol per g lyophilized microcapsules with 1 mM and 2 mM solutions, respectively. A dialysis experiment was then performed. After 1 h… CONTINUE READING