Cross-inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant.

@article{Ogawa1998CrossinhibitionOB,
  title={Cross-inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant.},
  author={Shunichi Ogawa and Satoshi Inoue and Akira Orimo and Takeshi Hosoi and Yasuyoshi Ouchi and Masami Muramatsu},
  journal={FEBS letters},
  year={1998},
  volume={423 2},
  pages={129-32}
}
Both estrogen receptor alpha (ERalpha) and the recently identified ERbeta are nuclear receptors that are activated by estrogen. It was reported that ERalpha and ERbeta form heterodimers. Here, we show that they activate transcription independently rather than synergistically via estrogen response elements (ERE). To show the cross-talk between ERalpha and ERbeta, we utilized dominant negative mutants of ERs constructed by C-terminal truncation. Interestingly, ERalpha1-530 inhibited… CONTINUE READING
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