Cross-inhibition between furin and lethal factor inhibitors.

  title={Cross-inhibition between furin and lethal factor inhibitors.},
  author={Juan Ram{\'o}n Peinado and Magdalena M Kacprzak and Stephen H Leppla and Iris Lindberg},
  journal={Biochemical and biophysical research communications},
  volume={321 3},
Bacillus anthracis synthesizes two toxins composed of the three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). The cleavage of PA on the cell surface by the convertase furin leads to the translocation of LF and EF into the cytosol. We have investigated the cross-inhibitory activities of the furin inhibitors hexa-d-arginine amide (D6R) and nona-d-arginine amide (D9R), which block the proteolytic activation of PA; and of the LF inhibitor In-2-LF, a peptide… CONTINUE READING
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