Cross-idiotypic Specificity among Monoclonal Igm Proteins with Anti-γ-globulin Activity

  title={Cross-idiotypic Specificity among Monoclonal Igm Proteins with Anti-γ-globulin Activity},
  author={Henry G. Kunkel and Vincent Agnello and Fenneke G. Joslin and Robert J. Winchester and J. Donald Capra},
  journal={The Journal of Experimental Medicine},
  pages={331 - 342}
Through the use of absorbed idiotypic antisera prepared against single isolated monoclonal IgM anti-gamma-globulins, partial cross-idiotypic specificity was demonstrated with other IgM anti-gamma-globulins. Such antisera classified these proteins into at least three groups. The major group which included 60% of the anti-gamma-globulins was particularly homogeneous. The anti-gamma-globulin specific antigens were detected best in hemagglutination and hemagglutination inhibition systems. They were… CONTINUE READING
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Cross idiotypic specificity among monoclonal IgM anti-'y-globulins

  • V. Agnello, F. G. Joslin, H. G. Kunkel
  • Scand. J. [mmunol
  • 1972

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