Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.

@article{Rabinowitz2004CrossdressingTV,
  title={Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups.},
  author={Joseph E. Rabinowitz and Dawn E. Bowles and Susan M. Faust and Julie Gunnells Ledford and Scott E Cunningham and Richard Jude Samulski},
  journal={Journal of virology},
  year={2004},
  volume={78 9},
  pages={4421-32}
}
For all adeno-associated virus (AAV) serotypes, 60 monomers of the Vp1, Vp2, and Vp3 structural proteins assemble via an unknown mechanism to form an intact capsid. In an effort to better understand the properties of the capsid monomers and their role in viral entry and infection, we evaluated whether monomers from distinct serotypes can be mixed to form infectious particles with unique phenotypes. This transcapsidation approach consisted of the transfection of pairwise combinations of AAV… CONTINUE READING