Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination.

Abstract

Activation of naïve cluster of differentiation (CD)8(+) cytotoxic T lymphocytes (CTLs) is a tightly regulated process, and specific dendritic cell (DC) subsets are typically required to activate naive CTLs. Potential pathways for antigen presentation leading to CD8(+) T-cell priming include direct presentation, cross-presentation, and cross-dressing. To… (More)
DOI: 10.1073/pnas.1203468109

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