Cross-competition between vasoactive intestinal peptide and somatostatin for binding to tumor cell membrane receptors.

@article{Virgolini1994CrosscompetitionBV,
  title={Cross-competition between vasoactive intestinal peptide and somatostatin for binding to tumor cell membrane receptors.},
  author={Irene Johanna Virgolini and Qiong Yang and Senlin Li and Peter Angelberger and Nikolaus Neuhold and Bruno Niederle and Werner Scheithauer and Peter Valent},
  journal={Cancer research},
  year={1994},
  volume={54 3},
  pages={690-700}
}
Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide with a wide range of biological activities. Recent data suggest that functional VIP receptors are expressed on various tumor cells. Somatostatin (SST) and its long-acting analogue octreotide (OCT) are potent inhibitors of tumor cell growth and secretion. In the present study, the interactions between VIP and SST/OCT on primary tumors (insulinomas, n = 3; VIPomas, n = 2; intestinal adenocarcinomas, n = 5; neuroblastomas, n = 5… CONTINUE READING
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